Article 2119

Title of the article

FEATURES OF DIAGNOSTICS AND TREATMENT OF VEGENER'S GRANULOMATOSIS 

Authors

Levina Tat'yana Mikhaylovna, Candidate of medical sciences, associate professor, sub-department of hospital therapy, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: tmlevina@mail.ru
Romanov Mikhail Dmitrievich, Doctor of medical sciences, professor, sub-departmet of hospital surgery, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: mdromanov@yandex.ru
Kireeva Ekaterina Mikhaylovna, Candidate of medical sciences, associate professor, sub-department of hospital surgery, Medical Institute, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: emkireeva@yandex.ru 

Index UDK

616.13-002:616-006.443 

DOI

10.21685/2072-3032-2019-1-2 

Abstract

Background. The aim of the study was to study the features of early diagnosis and treatment of Wegener's granulomatosis (granulomatosis with polyangiitis).
Materials and methods. The analysis of the features of diagnosis and treatment of Wegener's granulomatosis (WH) based on the materials of publications and own clinical observation of a limited variant of this disease, the harbinger of which was the torpid course of recurrent rhinitis with the formation of "crusts with hemorrhages" without increasing body temperature. The development of pneumonia with abscess formation compared to other minimal signs (sinusitis, otitis media, pain in the joints) allowed to suspect the presence of Wegener's granulomatosis and adequate complex therapy, which allowed to stop the processes of destruction and inflammation, and led to a stable remission of the disease.
Results and conclusions. An analysis of the features of the diagnosis and treatment of Wegener's granulomatosis based on publications and in the presented clinical observation demonstrates the need for an integrated approach in assessing the totality of early clinical signs (sinusitis, otitis, and upper respiratory tract pathology, etc.) characteristic of this disease. Early assignment of the starting complex (including immunosuppressive) ex juvantibus therapy aimed at preventing the progression of irreversible organ changes, despite its undesirable side effects, if at least two diagnostic criteria for WH are present, it will prevent further dramatic development of events and improve clinical results and prognosis. 

Key words

Wegener's granulomatosis, early diagnosis, immunosuppressive therapy, cyclophosphamide, rituximab 

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References

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Дата создания: 26.06.2019 09:08
Дата обновления: 26.06.2019 09:47